Convert MP4 to ISM
Converting .mp4 videos to .ism format.
How to convert mp4 to ism file
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Converting MPEG-4 Videos directly to IIS Smooth Streaming Manifest Files (.mp4 to .ism conversion) might perhaps be possible, even though your options are limited.
Try creating ISM files using the Free MP4 Splitter. Alternatively, you may try Azure Media Services.
Suggested software - mp4 to ism converters

Azure Media Services
Deliver content to virtually any device at scale with Live and On-Demand streaming.